Does DMAE Increase Choline? The Surprising Truth Revealed

DMAE (Dimethylaminoethanol) is often promoted as a cognitive enhancer and memory booster. A common question among users is, does DMAE increase choline levels in the brain? This article will delve into the effects of DMAE, provide recommended dosages for different experience levels, and review relevant scientific studies to offer a comprehensive answer.

What is DMAE?

DMAE is a compound similar to choline, an essential nutrient involved in neurotransmission and cell membrane integrity. DMAE is believed to enhance acetylcholine levels, a neurotransmitter crucial for memory and learning.

Dosage Recommendations

Beginner Dosage

For new users, starting with a low dose is key to assessing individual tolerance and effectiveness.

  • Dosage: 100-200 mg per day
  • Duration: Begin with a two-week trial
  • Form: Capsules and powder.
Intermediate Dosage

Once tolerance is established, users can increase the dosage to optimize cognitive benefits.

  • Dosage: 200-400 mg per day
  • Duration: 4-6 weeks
  • Form: Capsules, powder, or liquid
Expert Dosage

Experienced users may opt for a higher dosage to maximize cognitive enhancement.

  • Dosage: 400-600 mg per day
  • Duration: 6-8 weeks, followed by a break
  • Form: Capsules, powder, or liquid
DMAE Dosage Table

DMAE Dosage Recommendations

Experience Level Dosage Duration Form
Beginner 100-200 mg per day Two-week trial Capsules, powder
Intermediate 200-400 mg per day 4-6 weeks Capsules, powder, liquid
Expert 400-600 mg per day 6-8 weeks followed by a break Capsules, powder, liquid


Several studies have examined the effects of DMAE on choline levels and cognitive function. Here are some key findings:

  1. A study published in “Psychopharmacology” found that DMAE administration in rats resulted in increased acetylcholine levels in the brain, suggesting a potential mechanism for cognitive enhancement .
  2. Research in the “Journal of Neural Transmission” highlighted that DMAE supplementation led to improved memory and learning performance in animal models, indicating its possible benefits for human cognitive health .
  3. A clinical trial reported in “Pharmacology, Biochemistry, and Behavior” observed that DMAE improved attention and vigilance in healthy adults, supporting its use as a nootropic .
  4. A study on PubMed found that DMAE supplementation in animals showed positive effects on memory ability and potency, suggesting a link between DMAE and increased choline levels .

Benefits of DMAE

  • Enhanced memory and learning: By potentially increasing acetylcholine levels, DMAE may support cognitive functions crucial for memory and learning.
  • Improved mood and focus: Some users report better mood and mental clarity.
  • Neuroprotective effects: DMAE’s antioxidant properties may protect brain cells from oxidative stress.

Potential Side Effects

While DMAE is generally well-tolerated, some users may experience side effects, including:

  • Headaches
  • Insomnia
  • Muscle tension

Starting with a low dose and gradually increasing it can help minimize the risk of side effects.


So, does DMAE increase choline? While the evidence suggests that DMAE may boost acetylcholine levels and offer cognitive benefits, individual responses can vary. Starting with a low dose and adjusting based on tolerance and effectiveness is crucial.


  1. Psychopharmacology: Link to study
  2. Journal of Neural Transmission: Link to study
  3. Pharmacology, Biochemistry, and Behavior: Link to study
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